New and efficient synthesis of dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates-Science-Chemical Encyclopedia-lookchem

New and efficient synthesis of dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates
Add time:08/14/2019 Source:sciencedirect.com

The condensation product of Meldrum's acid and 4-nitrobenzaldehyde reacts smoothly with alkyl isocyanides in the presence of alcohols to produce dialkyl 2-[1-p-nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates in excellent yield. This reaction provides a useful synthetic route to highly functionalized amidodiesters.

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