Add time:08/12/2019         Source:sciencedirect.com

Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A series of influenza neuraminidase inhibitors with the pyrrolidinobenzoic acid scaffold containing lipophilic side chains at the C3 position have been synthesized and evaluated for influenza neuraminidase inhibitory activity. The size and geometry of the C3 side chains have been modified in order to investigate structure–activity relationships. The results indicated that size and geometry of the C3-side chain are important for selectivity of inhibition against N1 versus N2 NA, important type A influenza variants that infect man, including the highly lethal avian influenza.

We also recommend Trading Suppliers and Manufacturers of 2-BROMOPROPIONIC-1-13C ACID (cas 100900-34-3). Pls Click Website Link as below: cas 100900-34-3 suppliers