Add time:08/12/2019         Source:sciencedirect.com

Chiral selector-functionalized magnetic microspheres have significantly potential in the recognition and separation of chiral compounds. In this work, novel chiral selector-functionalized magnetic microspheres (l[email protected]) were achieved by grafting l-valine (l-Val) on polyamidoamine (PAMAM) dendrimer-modified magnetic microspheres, which were confirmed by various characterization methods. The synthesized l[email protected] had clearly three-layer structure, with a mean diameter of 590 nm and exhibited good dispersion and strong magnetic response. The immobilization amounts of l-Val determined by high performance liquid chromatography with mass spectrometry (HPLC–MS) increased with increasing PAMAM generation, and the results indicated that the PAMAM dendrimer bonded onto the surface of magnetic microspheres obviously improved the immobilization amounts of l-Val. The synthesized l[email protected] as chiral magnetic selectors were used to conduct the enantioselective adsorption of dansyl amino acids. The chiral discrimination ability of the l[email protected] was investigated through determining the enantiomeric excess of the l[email protected] with capillary electrophoresis. Under the optimal amount of l[email protected] and interaction times, the enantiomeric excess of dansyl amino acids adsorbed onto the surface of the l[email protected] was calculated to be 20.1%. The results of enantiomeric excess indicated that the l[email protected] selectively interacted with dansyl amino acid and exhibited excellent chiral discrimination ability. In the future research, the novel l[email protected] are possible to be an efficient and suitable chiral selector for the enantioseparation of chiral compounds.

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