Add time:08/13/2019         Source:sciencedirect.com

The effects of grinding on the crystallinity of cephalothin sodium, and on the chemical stability of the ground products were investigated by X-ray diffraction, infrared spectra and differential thermal analysis. The X-ray diffraction peaks of all samples decreased after grinding, but the diffraction profiles had no halo pattern. This suggests that part of the cephalothin sodium was converted into a noncrystalline solid. The crystallinity of cephalothin sodium decreased with increased grinding time during the initial grinding process, and cephalothin sodium ground for 2 h was about 30% crystalline. However, the crystallinity increased after grinding for 3–10 h, reaching equilibrium at about 50%. The decomposition point, measured by differential thermal analysis of the ground products, fell rapidly during early grinding, and then decreased from 202 to 187°C after 2 h. However, it rose to 191°C after 3 h and thereafter stayed at approx. 192°C. The water content of intact cephalothin sodium increased at more than 95% relative humidity (R.H.). The water content after grinding for 2 or 10 h increased at more than 93% R.H. The results suggest that the chemical stability in the solid state and the hygroscopicity of cephalothin sodium are closely related to the crystallinity.

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