Add time:08/12/2019         Source:sciencedirect.com

Treatment of the salt CF3CCLi with alkyl chloroformates affords the compounds CF3CCCO2R (R  Et and CH2Ph) in relatively low yield and with gaseous carbon dioxide yields the acid CF3CCCO2H. Reaction of the acid with diazomethane gives the methyl ester which, with an excess of the reagent, undergoes regiospecific 1,3-dipolar cycloaddition to produce 3-carbomethoxy-4- trifluoromethylpyrazole and hence the 3- and 5-carbomethoxy-1-methyl-4- trifluoromethylpyrazoles. Oxidation of the alcohol CF3CCCH(OH)Ph (active MnO2) affords a 70:23 mixture of 3-benzoyl-2,4-bis(trifluoromethyl)-2-hydroxy-6- phenyl-α-pyran and E-1,3-dibenzoyl-2-trifluoromethylpropene (via the ketone CF3CCCOPh).

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