Add time:08/12/2019         Source:sciencedirect.com

Mutations induced by substances formed during food cooking are a field of growing interest; for a better comprehension of the mechanism of action of these carcinogens, simple routes to their synthesis are needed. In this letter we describe an easy method for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) synthesis, starting from the commercially available 2,3-diaminopyridine 1 via the 2-amino-3-methylamino-5-phenylpyridine 5 formation. The key step of this approach is the one pot synthesis of 5 performed by photolysis of 2-amino-5-iodo-3-(N-methyl-N-tosylamino)pyridine 4 to obtain simultaneous phenylation and tosyl group removal. Compound 5 was then used as an intermediate to obtain the 1-methyl-6-phenylimidazo[4,5-b]pyridine6 which was aminated to afford PhIP in good overall yields.

We also recommend Trading Suppliers and Manufacturers of 2-AMINO-3-METHYLAMINO-5-PHENYLPYRIDINE (cas 107351-81-5). Pls Click Website Link as below: cas 107351-81-5 suppliers