Add time:08/14/2019         Source:sciencedirect.com

A facile, efficient and environment-friendly protocol for the synthesis of 4-hydroxy-6-methyl-3-(1-(phenylimino)ethyl)-2H-pyran-2-one derivatives has been developed by the convenient ultrasound-mediated condensation of amine with dehydroacetic acid. This method provides several advantages over current reaction methodologies including a simple work-up procedure, shorter reaction times and higher yields.

► A series of 4-hydroxy-6-methyl-3-(1-(phenylimino)ethyl)-2H-pyran-2-one derivatives have been synthesized under ultrasound irradiation. ► Ultrasonic irradiation was found to have beneficial effect on the synthesis of these Schiff bases. ► All the proposed reactions allowed the preparation of products in good yield without any further complicated refinement.

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