Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: A three-way crossover study-Science-Chemical Encyclopedia-lookchem

Effect on the development of ankle edema of adding delapril (cas 110508-92-4) to manidipine in patients with mild to moderate essential hypertension: A three-way crossover study
Add time:08/16/2019 Source:sciencedirect.com

Background:Use of the combination of an angiotensinconverting enzyme inhibitor (ACEI) and a calcium channel blocker (CCB) is considered a rational approach in patients whose hypertension is not controlled by monotherapy, providing better blood pressure (BP) control than the individual components with a lower incidence of adverse effects. In particular, such combinations have been found to reduce the incidence of ankle edema, the most common adverse effect of dihydropyridine annhypertensives.

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