Add time:08/14/2019         Source:sciencedirect.com

2,4,5-Trichlorophenoxyacetate (2,4,5-T) has been shown to undergo renal tubular secretion in the isolated perfused rat kidney, especially when a dextran perfusate was used to limit 2,4,5-T-colloid binding. This renal transport of 2,4,5-T led to a high concentration of 2,4,5-T in the kidney and a resultant decrease in the functional capacity of the perfused kidney. The present study investigated the effect of 2,4,5-T on in vivo renal function in the rat. When 100 mg 2,4,5-T/kg was infused iv, no effect on renal function was observed; glomerular filtration rate (GFR), fractional reabsorption of water and electrolytes, (FRH2O, FRNa, FRK, FRCl), urine flow rate (V̇) and clearance of tetraethylammonium (CTEA) were unaltered. One possibility for the discrepancy between the findings in the perfused kidney and in the in vivo experiments was the high degree of plasma binding of 2,4,5-T found in rat plasma. This plasma-protein binding, which has been known to decrease 2,4,5-T excretion, appeared to protect the kidney from the compound's acute nephrotoxic effects. To test this hypothesis, perfused-kidney experiments were performed with 2,4,5-T in a bovine serum-albumin perfusate. Under these conditions, there was no change in the GFR, V̇, FRNa, FRH2O and FRCl. The clearance of p-aminohippurate (CPAH), however, was reduced in the presence of 2,4,5-T. The CPAH/GFR was decreased from about 6 to 1, which indicated that organic-anion transport was completely inhibited by a 2,4,5-T concentration that was not nephrotoxic. Thus 2,4,5-T did not produce acute renal failure in vivo but was still able to cause a selective inhibition of organic-anion transport in the kidney.

We also recommend Trading Suppliers and Manufacturers of sodium 2,4,5-trichlorophenoxyacetate (cas 13560-99-1). Pls Click Website Link as below: cas 13560-99-1 suppliers