Add time:08/21/2019 Source:sciencedirect.com
Aliphatic and aromatic azido derivatives of semotiadil (1), a novel calcium antagonist with a 1,4-benzothiazine skeleton, were synthesized for developing photoaffinity probes of L type calcium channels. The azidophenoxy derivative 12 proved to be a potent calcium antagonist and its [3H]-labeled compound 16 would be a useful tool to clarify the binding sites of 1 to the calcium channels.
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