Add time:08/15/2019         Source:sciencedirect.com

An investigation on the comparative mutagenic activity of N-nitroso-N-methylurethane (NMU) and N-nitroso-N-ethylurethane (NEU) in Schizosaccharomyces pombe was carried out. NMU, NEU and four related compounds were tested for reversion to methionine independence on teh met4-, D 19, h- strain, NMU was found to be much more mutagenic and toxic than NEU. A genetic analysis of the revertants induced by NMU and NEU did not reveal any difference between the two mutagens as to proportion of reversions due to suppressor mutations. For both NMU and NEU, mutagenic activity and breakdown of the compound increased with increasing pH.Urethane, N-methylurethane and N-ethylurethane, tested in the same conditions as NMU and NEU, were not mutagenic; the mutagenic activity of nitrous acid was much lower than that of the nitroso compounds.The results confirm the hypothesis that the mutagenic activity of nitroso compounds is due to the production in the cell of diazoalkanes, whose formation in vitro is known to be favoured by alkali conditions.

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