Add time:08/19/2019         Source:sciencedirect.com

A method for a fast quantitative determination of the l-isomer in d-penicillamine is described. l-Leucine is coupled to d,l-penicillamine and the resulting diastereomers separated by reversed phase liquid chromatography. The mild conditions for the derivatization cause no racemization. For detection the UV-absorption of the derivatives at a wavelength of 215 nm is used. A linear signal was gained in a concentration range of 0.05–10% l-isomer in d-penicillamine. One complete determination can be carried out in 1.5–2 h. A comparison of products from different manufacturers resulted in the detection of l-penicillamine in the material of only one producer.

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