The Ugi reaction with 2-substituted cyclic imines. Synthesis of substituted proline and homoproline derivatives-Science-Chemical Encyclopedia-lookchem

The Ugi reaction with 2-substituted cyclic imines. Synthesis of substituted proline and homoproline derivatives
Add time:08/14/2019 Source:sciencedirect.com

The Ugi three-component reaction with 2-substituted five-, six-, and seven-membered cyclic imines was investigated. The reaction opens a new route to substituted proline and homoproline derivatives. It was shown that the method is efficient for the one-step preparation of seminatural dipeptides containing natural amino acid residues, and fragments of substituted proline or pipecolinic acid. The scope and limitation of the approach are discussed.

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