Add time:08/13/2019         Source:sciencedirect.com

The solubility of d-aspartic acid in co-solvent mixtures of dimethyl sulfoxide (DMSO) (1) + water (2), N,N-dimethylformamide (DMF) (1) + water (2), N-methyl-2-pyrrolidone (NMP) (1) + water (2) and 1,4-dioxane (1) + water (2) at the temperatures from (288.15/298.15 to 333.15) K was reported. Experiments were performed through the saturation shake-flask technique. The maximum solubility values were observed in the neat DMF (DMSO, NMP and 1,4-dioxane) for the four aqueous co-solvent mixtures. Through the Jouyban-Acree model, the d-aspartic acid solubility was well correlated attaining RAD values less than 2.55% and RMSD values less than 2.81 × 10−4. The local mole fractions of DMSO (DMF, NMP or 1,4-dioxane) and water nearby the d-aspartic acid were analyzed through the Inverse Kirkwood–Buff integrals method. d-Aspartic acid was preferentially solvated by water in water-rich compositions; while within intermediate and co-solvent-rich compositions, d-aspartic acid was preferentially solvated by DMF (NMP or 1,4-dioxane) in DMF (NMP or 1,4-dioxane) + water mixtures. In addition, the model of Kamlet and Taft linear solvation energy relationships was employed in order to rationalize the co-solvency effect and to identify its main components. It was found that the work needed for breaking solvent-solvent interactions presented by cavity term mainly controlled the solubility enhancement over the entire composition range in all the aqueous binary mixtures.

We also recommend Trading Suppliers and Manufacturers of DIMETHYL ASPARTIC ACID (cas 1115-22-6). Pls Click Website Link as below: cas 1115-22-6 suppliers