Add time:08/13/2019         Source:sciencedirect.com

Publisher SummarySulfinic acids (RSO2H) are moderately stable compounds of limited natural occurrence. Only cysteinesulfinate and hypotaurine have been detected in tissues or physiological fluids of normal animals. Two additional sulfinic acids, β-sulfinopyruvate and β-sulfinoacetaldehyde, are formed in vivo but spontaneously decompose with loss of SO2. Homocysteinesulfinate has been detected in the urine of patients with homocystinuria. In addition to studies of their role as sulfur amino acid metabolites, sulfinic acids have received considerable attention as analog of carboxylic acids. Cysteinesulfinic acid, an analog of aspartic acid, is, for example, effectively transaminated by aspartate aminotransferase in vitro and in vivo and is desulfinated by bacterial aspartate β-decarboxylase. Cysteinesulfinate and homocysteinesulfinate are transported by the dicarboxylic amino acid carriers present in many biological membranes. The procedure of synthesis of L-[35S]Cysteinesulfinic acid described in the chapter includes radiolabeled cystine and other amino acid disulfides; formation of thiosalfonate intermediate; cleavage of the thiosulfonate intermediate; purification of L-[35S]cysteinesulfinate; and evaluation of product.

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