Add time:08/13/2019         Source:sciencedirect.com

A new class of compounds, the thiopyrano[2,3-e]indol-2-ones, bioisosters of the angular furocoumarin angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents. In particular 7,8-dimethyl-thiopyranoindolone 6c s showed a remarkable phototoxicity and a great dose UVA dependence reaching IC50 values at submicromolar level. This latter photoinduced a massive apoptosis and a remarkable photodamage to lipids and proteins. Although it did not intercalate DNA, it was able to cause photooxidation of DNA bases.

We also recommend Trading Suppliers and Manufacturers of 2,3-(di-glutathion-S-yl)-1,4-naphthoquinone (cas 107432-96-2). Pls Click Website Link as below: cas 107432-96-2 suppliers