Add time:08/14/2019 Source:sciencedirect.com
Chiral 3-aryloxy-1,2-propanediols of >98% ee can be obtained in high yield by the nucleophilic addition of substituted phenols to chiral glycidol in the presence of triethylamine catalys followed by recrystallization in absolute ethanol. Several enantiopure compounds of pharmaceutical significance are presented as examples.
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