Add time:08/14/2019         Source:sciencedirect.com

Propoxyphene napsylate was studied in reproduction and teratology experiments in rats and in a teratology experiment in rabbits. Rats were given daily oral doses of 0, 100, 200, or 400 mg/kg, while rabbits were treated with oral doses of 0, 32, or 80 mg/kg/day. In neither species were there any signs of druginduced teratogenicity. Large doses of the drug (200, 400 mg/kg/day) impaired the reproductive capacity of mating or pregnant female rats (i.e., reduced fertility, stunting and decreased viability of the progeny), but these doses also induced distinct maternal toxicity; daily doses of 200 or 400 mg/kg resulted in the death of approximately 20% of the female rats.

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