Add time:08/16/2019         Source:sciencedirect.com

The absorption of PROPOXYPHENE NAPSYLATE (cas 17140-78-2) from tablets, capsules, and a suspension formulation, as measured by concentrations in the plasma of 10 human male subjects, reveals that the tablet and capsule are equivalent solid dosage forms. The suspension affords a significantly higher plasma concentration of propoxyphene at 1 hr after ingestion than does either the tablet or capsule. This is correlated with significantly greater availability of propoxyphene from the suspension between 0 and 6 hr. Tablets of propoxyphene napsylate and aspirin with and without phenacetin and caffeine tended to produce higher plasma propoxyphene concentrations than do tablets containing only propoxyphene napsylate. Plasma concentrations of salicylate are not affected by the presence of propoxyphene napsylate in the tablet.Tablets and capsules containing propoxyphene napsylate, aspirin, phenacetin, and caffeine in equal amounts yield statistically equivalent plasma concentration curves of propoxyphene and salicylate.

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