Add time:08/19/2019 Source:sciencedirect.com
A balanced Latin square design was used to evaluate the effectiveness and acceptability of 2 propoxyphene salts in consenting postpartum patients with pain. Attention was paid to the intensity of pain and its change on treatment, an estimate of pain relief, and the frequency and intensity of symptoms other than pain. Analgesia scores were calculated from change in pain intensity and estimate of relief. The initial pain intensity had a significant linear relationship to the analgesia score, to the onset and duration of analgesia, and to the number and intensity of other symptoms. Greater analgesia and an earlier onset were observed with propoxyphene than with the blank control. The response to propoxyphene (as measured by the onset and duration of analgesia and the frequency and intensity of other symptoms) was linear to the log dose. The napsylate salt had a significantly longer duration of action, which may account for its apparently greater potency. Other symptoms were reported less frequently and were of a lower intensity after the napsylate than after the hydrochloride salt.
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