Add time:08/14/2019         Source:sciencedirect.com

The preparation and preliminary evaluation of 2, an analog of sandramycin, are detailed. Although 2 was typically 4–10x less potent than sandramycin against leukemia cell lines, it was found to be 1–10,000x more potent against melanomas, carcinomas, and adenocarcinomas exhibiting typical IC50 values of 200-1 pM and placing it among the most potent agents identified to date.

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