Add time:08/14/2019         Source:sciencedirect.com

Nucleophilic substitution of 5-bromotriazoloisoquinoline (3) and of 7-bromo-3-methyltriazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloisoquinolines (4a)-(4e), and of 7-substituted triazolopyridines (7a)-(7h) respectively. Triazoloisoquinolines have been converted into 1,3-disubstituted isoquinolines (11)-(13), (15), and (16), and triazolopyridines into 2,6-disubstituted pyridines (17)-(19). Of secondary amine nucleophiles, only piperidine reacted with 7-bromo-3-methyltriazolopyridine (6) to give the 7-substituted derivative (7g). A second product in this reaction was a 2,6-disubstituted pyridine (8); the similar compounds (20)-(24) were the only products when morpholine or N-acetylpiperazine were used. The reaction between 7-bromotriazolopyridine (9) and piperidine or morpholine gave in high yield the 2,6-disubstituted pyridines (25) and (26).

We also recommend Trading Suppliers and Manufacturers of 7-broMo-[1,2,3]triazolo[1,5-a]pyridine (cas 107465-26-9). Pls Click Website Link as below: cas 107465-26-9 suppliers