Add time:08/14/2019         Source:sciencedirect.com

A new fluorinated analogue of 1-aminocyclobutane-1-carboxylate (ACBC) – 1-amino-3,3-difluorocyclobutanecarboxylic acid (6) – has been synthesized in six steps from acetone. The key step of the synthesis is a transformation of a ketone group into the CF2-group using morpholino-sulphur trifluoride.

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