Add time:08/18/2019         Source:sciencedirect.com

Momordica charantia L. has been widely used in different countries as a functional food source, particularly as a remedy for type 2 diabetes. In the present study, 21 cucurbitane-type triterpenoids, including two new compounds named charantoside IX and X (1−2), were isolated from the extract of M. Charantia L. Their chemical structures were identified by 1D, 2D-NMR and FT-ICR-MS techniques. Three anti-diabetes target assays of all triterpenoids were carried out, with all compounds exhibiting α-glucosidase inhibitory activity. Particularly, compounds 6, 9 and 11 exhibited excellent α-glucosidase inhibitory activity with IC50 values of 10.19, 28.55, and 20.20 μM, respectively. Some of the tested isolates showed inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) and α-amylase, with compound 6 exhibiting the strongest activity against PTP1B. These chemical and biological results indicated that cucurbitane triterpenoids in functional foods may represent attractive candidates for regulation of blood glucose levels.

We also recommend Trading Suppliers and Manufacturers of L-Tyrosine, 3-Methoxy-O-Methyl-, ethyl ester (cas 104528-83-8). Pls Click Website Link as below: cas 104528-83-8 suppliers