Add time:08/15/2019 Source:sciencedirect.com
A validated ion chromatographic method for the determination of anionic impurities in CLODRONIC ACID (cas 10596-23-3) or disodium clodronate is described. Separations are performed by using an anion-exchange column (IonPac AS5) and a sodium hydroxide gradient. Impurities are detected by suppressed conductivity without the need for derivatisation. The most important variable affecting the separation was shown to be the column temperature.
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