Add time:08/18/2019 Source:sciencedirect.com
Novel partial amides of clodronic acid were synthesized and evaluated in vitro for their properties as bioreversible prodrugs of clodronate. The hydrolysis studies indicated that these derivatives release the parent drug via chemical hydrolysis. Monoamides were hydrolysed rapidly (t1/2=16–19 min at pH 7.4) to clodronic acid, which suggests that they are useful intermediates in the design of enzymatically labile double prodrugs of clodronate.
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