Add time:08/15/2019 Source:sciencedirect.com
Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57–99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(−)-epinephrine, (R)-(−)-norepinephrine and (R)-(−)-isoproterenol.
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