Add time:08/15/2019         Source:sciencedirect.com

1.1. The effect of a single intravenous dose of scillaren (cas 11003-70-6) B on the blood pressures in the lesser circulation, and the clearance values for inulin and para-aminohippurate as well as sodium excretion were studied in six patients with rheumatic heart disease.2.2. Heart rate rapidly decreased, in some cases during the first minute after administration.3.3. Pulmonary blood pressures fell rapidly, while cardiac output remained unchanged. Stroke index rose considerably.4.4. No effect on clearance values or sodium excretion was noticed.5.5. Compared with lanatoside C, Scillaren B acts with shorter latency on pulmonary pressures in patients with mitral stenosis, but does not show any of the prompt, direct renal effects of the digitalis drug.6.6. Scillaren B is a swift and potent cardiac drug. The renal action which has been described earlier is secondary to its effect on the heart.

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