Add time:08/19/2019         Source:sciencedirect.com

A subchronic toxicity study of Methyl hesperidin (cas 11013-97-1) was performed using B6C3F1 mice. The flavonoid was administered to groups often males and ten females in dietary levels of 0, 0.3, 0.6, 1.25, 2.5 and 5.0% for 13 weeks. No significant treatment-related differences were found in data for body weights, food and water consumption, hematology, clinical chemistry and organ weights. Furthermore, no effects of treatment were observed on gross and histopathological examination of the major organs. The present experiment thus demonstrated that methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.

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