Add time:07/14/2019         Source:sciencedirect.com

Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (5a–j) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (7a–j) were prepared. In continuation of a previously reported study, the first series (5a–j) were synthesized by the cyclocondensation of 4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (4) with various substituted aromatic carboxylic acids in phosphorus oxychloride and the second series (7a–j) by the reaction of (4) with various substituted aromatic aldehydes in the presence of p-Toluene sulfonic acid. Reaction of (4) with the aldehyde (9) afforded the Schiff's base (10) and not the cyclised product (11) on treatment with p-Toluene sulfonic acid. Synthesized compounds were structurally confirmed by spectral analysis and studied for their anti-inflammatory, analgesic, anti-oxidant and antimicrobial activities. Some of the tested compounds showed significant pharmacological activities.

We also recommend Trading Suppliers and Manufacturers of 3-(3-chlorophenyl)-6-(2-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (cas 573949-13-0). Pls Click Website Link as below: cas 573949-13-0 suppliers