Add time:08/16/2019         Source:sciencedirect.com

Two series of 1,4-dihydropyridines related to tiamdipine (cas 110646-15-6), 2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1, 4-dihydropyridine, have been evaluated for their pharmacologic and radioligand binding properties in smooth and cardiac muscle. In the tiamdipine series the influence of phenyl ring substitution, 3-C1, 3-MeO and 3-CF33, was greatly reduced relative to the N-formyl and neutral nifedipine derivatives. Consistent wkh our previous observations onset and offset of action were greatly reduced by the presence of the amine side chain. In tiamdipine analogs also bearing an asymmetric substituent at C-2, chirality at C-4 was determinant for activity.

We also recommend Trading Suppliers and Manufacturers of tiamdipine (cas 110646-15-6). Pls Click Website Link as below: cas 110646-15-6 suppliers