Add time:08/17/2019         Source:sciencedirect.com

Orally administered all-trans retinoyl β-glucuronide, after its absorption from the intestine, is distributed widely in the tissues, except for brain, of both vitamin A-sufficient (A+) and vitamin A-deficient (A−) rats. Although the digestion and rate of absorption of retinoyl β-glucuronide are similar in A+ and A− rats, the rates of hydrolysis of retinoyl β-glucuronide to retinoic acid markedly differ. Thus, after an oral dose (6.3 μmol) of all-trans retinoyl β-glucuronide in corn oil, retinoic acid peaks at 4 hr in the plasma at a concentration of 2.5 to 4.2 μM in A− rats, up to 40-fold higher than in A+ rats. The peak retinoic acid concentration in A− rats increased with the severity of the deficiency. Similarly, the ratio of retinoic acid/retinoyl β-glucuronide in various tissues of A− rats is 1.3 to 12.5-fold higher than in those of A+ rats. In the absence in tissues of retinol or its ester, A− rats clearly use administered retinoyl β-glucuronide as a ready source of retinoic acid.

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