Add time:08/15/2019         Source:sciencedirect.com

Publisher SummaryThis chapter describes the physicochemical properties, synthesis, stability, biopharmaceutical aspects, acute toxicities of, as well as analytical methods for dibenzepin hydrochloride. The drug shows remarkable histaminolytic and anti-anaphylactic effects and this antidepressant can be classified among the thymoleptic drugs between Imipramine and amitryptiline, based on clinical trials. The differential scanning calorimetry (DSC) curve shows only a sharp melting endotherm accompanied by decomposition or sublimation. No loss of weight is observed until melting. A strong loss of weight is observed during the melting process. Catalytic hydrogenation of 2-[methyl(2-nitrophenyl)-aminolbenzoic acid methylester leads to the corresponding aminoester, 2-[(2-arninophenyl)methylamino]benzoic acid methylester, which is then converted by cyclization with a strong base to the lactam 5,10-dihydro-5-methyl-11H-dibenzo[b,e][l,4]diazepin-l-one. Alkylation with 2-chloro-N, N-dimethylethanamine yields dibenzepin base, whose hydrochloride is formed by reaction with gaseous hydrochloric acid in ethanolic solution. Dibenzepin hydrochloride is a very stable substance; its degradation could only be observed in acid solution under drastic conditions.

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