Modified tert-butoxycarbonyl(m-BOC) derivatives as monomeric and polymeric aminoprotecting groups — VII-Science-Chemical Encyclopedia-lookchem

Modified tert-butoxycarbonyl(m-BOC) derivatives as monomeric and polymeric aminoprotecting groups — VII
Add time:08/16/2019 Source:sciencedirect.com

Polymerizable N-methacrylamino m-BOC-type 1,1-dimethyl-2-methacrylmethanamido-ethoxy-carbonyl- and 1,1-dimethyl-3-methacrylmethanamido-butoxy-carbonyl group, derived from the corresponding t-alkohols have been developed as acid labile aminoprotecting groups. The synthesis of monomeric and polymeric N-methacrylamino m-BOC amino acids and amino acid methyl esters and their application for peptide synthesis following the (N→C)-assembly method are described. The rapid, acid induced cleavage of the protecting group leads to the formation of oxazole resp oxazine derivatives.

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