Add time:08/16/2019 Source:sciencedirect.com
Knoevenagel condensation between 3-nitro-2-pyridinecarbaldehyde and diethyl malonate catalyzed by titanium(IV) chloride gave diethyl 3-nitro-2-pyridylidenemalonate which was oxidized with peracetic acid to give corresponding 1-oxide. Reaction of the latter with diethylamine in the presence of primary and secondary alcohols resulted in the reduction of the nitro group and the oxidation of the vinylic carbon attached to the pyridine ring. Simultaneous migration of the malonic fragment gave the appropriate 3-amino-2-pyridinecarboxylate esters. The 4-nitro-3-pyridylidenemalonate 1-oxide rearranges into the corresponding 4-amino-3-pyridinecarboxylate analogue.
We also recommend Trading Suppliers and Manufacturers of 2-Methoxy-4-nitropyridine 1-oxide (cas 14395-39-2). Pls Click Website Link as below: cas 14395-39-2 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View