Add time:08/25/2019         Source:sciencedirect.com

porphyran (cas 11016-36-7), the sulfated polysaccharide from red algae Porphyra haitanensis, possesses excellent bioactivities, especially the immune activity. In order to provide a water-soluble macromolecule prodrug of 5-FU showing slow release of 5-FU, reducing side-effect, we employed porphyran as a drug carrier, and carried out fixation of 5-FU to porphyran at 6-position through acetyl spacer group via ester bond. The chemical characteristic and release behavior of 5-FU from the conjugate obtained were studied in vitro at 37 °C in three different medium. The results represented that the release mechanism of all the conjugates was a typical Fickian diffusion. However, further in vivo studies on animal models are necessary to establish the efficiency of the system.

We also recommend Trading Suppliers and Manufacturers of porphyran (cas 11016-36-7). Pls Click Website Link as below: cas 11016-36-7 suppliers