Add time:08/22/2019 Source:sciencedirect.com
Preliminary findings on the possible important role of the N-3 sugar moiety of coformycin (cas 11033-22-0) in its tight-binding interaction with adenosine deaminase (ADA) are reported. The compound 3-β-D-Ribofuranosyl-5,6,7,8tetrahydro-4H-imidazo[4,5-d][1,3]diazepin-5-one-8-ol (1), its 3-benzyl analogue (6), and the aglycon (7) served as probes. The first two were both found to be competitive inhibitors of ADA with Ki's in the range of 10−5M,while the last one was inactive.
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