Add time:08/21/2019 Source:sciencedirect.com
Covalent binding of the antitumour antibiotic hedamycin to the self-complementary hexadeoxyribonucleotide 5′-CACGTG-3′ has been investigated by electrospray ionization mass spectrometry (ESI-MS). Ions due to double-stranded forms of the free 5′-CACGTG-3′ and the hedamycin-5′-CACGTG-3′ adduct have been observed in ESI mass spectra and their identity has been confirmed by resolution of individual charge states in ESI-MS spectra. Clear evidence that specific base-paired associations are being observed in ESI-MS is provided by the results of a titration experiment involving alkylated and non-alkylated complementary strands. This work demonstrates the potential of this powerful new tool for studying ligand-DNA binding.
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