Methyl 5-0-tert-butyldiphenylsilyl-2-deoxy-α β -d-threo-pentofuranoside as a divergent intermediate for the synthesis of 3'-substituted-2',3'-dideoxynucleosides: synthesis of 3'-azido-3'-deoxythymidine, 3'-deoxy-3'-fluorothymidine and 3'-cyano-3'-deoxythymidine.-Science-Chemical Encyclopedia-lookchem

Methyl 5-0-tert-butyldiphenylsilyl-2-deoxy-α β -d-threo-pentofuranoside as a divergent intermediate for the synthesis of 3'-substituted-2',3'-dideoxynucleosides: synthesis of 3'-azido-3'-deoxythymidine, 3'-deoxy-3'-fluorothymidine and 3'-cyano-3'-deoxythymidine.
Add time:08/19/2019 Source:sciencedirect.com

The use of methyl 5-0-tert-butyldiphenylsilyl-2-deoxy-α , β -D-threo-pentofuranoside, prepared from D-xylose,as a divergent intermediate for the synthesis of 3'-substituted-2',3'-dideoxynucleosides is illustrated by its conversion into 3'-azido-3'-deoxythymidine, 3'-deoxy-3'-fluorothymidine and 3'-cyano-3'-deoxythymidine.

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