Add time:08/17/2019 Source:sciencedirect.com
A method is described for labeling proteins with 7.2 h half-life 211At. The α particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce 211At-labeled IgG in 25–40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the 211At-labeled IgG conjugate is stable in vivo.
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