Add time:08/20/2019 Source:sciencedirect.com
A new method is reported for the synthesis of N-succinimidyl p-([125127I]iodobenzoate (NS-p-IB) from N-succinimidyl p-(tri-n-butylstannyl)benzoate via an iodination-destannylation reaction. The tin precursor was obtained in 70% overall yield from p-bromobenzoyl chloride after a four-step synthesis. The radiochemical yield of NS-p-[125I]IB was 75%. Conjugation of NS-p-[125I]IB to rabbit IgG or bovine serum albumin gave yields of 52 and 60% respectively. In vitro the radiolabeled proteins in serum at 37 °C showed <1% deiodination by 24 h. In vivo the stability of mouse IgG (MIgG) labeled with NS-p-[125I]IB was superior to MIgG radioiodinated in the presence of chloramine-T.
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