Add time:08/20/2019 Source:sciencedirect.com
A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or drugs, which were obtained in generally good to excellent yield.
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