Add time:08/18/2019         Source:sciencedirect.com

Among a series of taxinine (1) and its designed derivatives (2 ∼ 33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14 ∼ 16, 22, and 30 ∼ 32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.

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