Add time:08/16/2019         Source:sciencedirect.com

Metformin hydrochloride is an orally administered biguanide which is an oral anti-hyperglycemic agent. It shows incomplete absorption from the gastrointestinal tract and the absolute bioavailability is 50–60% with relatively short plasma half-life of 1.5–4.5 h. In this study the host-guest complexation of hydroxypropyl-α-cyclodextrin with Metformin hydrochloride is discussed. Inclusion complexes of Metformin hydrochloride with hydroxypropyl-α-cyclodextrin were prepared in solid and liquid state and they are characterized using spectrophotometry, fluorimetry, 1H NMR and phase solubility studies. The subsistence of host-guest interaction makes hydroxypropyl-α-cyclodextrin a suitable candidate for the enhancement of bioavailability of Metformin hydrochloride.

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