Add time:08/17/2019         Source:sciencedirect.com

A sensitive electroanalytical method for the quantification of Betahistine Hydrochloride (cas 15430-48-5) in pharmaceutical formulation has been developed on the basis of an enhanced electrochemical response at glassy carbon electrode modified with polyaniline–zinc oxide (PANI–ZnO). Results suggest that betahistine hydrochloride in sodium lauryl sulfate (SLS) exhibits an electrocatalytic effect resulting in a marked enhancement of the peak current. The electrochemical performance of the modified PANI–ZnO/GCE sensor was investigated by cyclic voltammetry and square wave voltammetry (SW). Calibration plot reveals linearity within the range 25–515 μg/mL with a correlation coefficient of 0.997. A lower limit of detection of 19.57 μg/mL proved the sensitivity of the proposed method.

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