Add time:08/16/2019         Source:sciencedirect.com

Here, we have established a simple and an efficient methodology for the synthesis of spirocyclic α-amino acids as well as spirosulfones starting with readily available active methylene compounds (AMCs). The key di-bromo building blocks were assembled by reacting various active methylene compounds with 1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE (cas 15442-91-8) in one step. We have also expanded this strategy to generate a variety of bis-spirocycles by treating the di-bromo intermediates with different AMCs under operationally simple reaction conditions.

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