Add time:08/16/2019         Source:sciencedirect.com

N(α)-(2-Oxo-2H-1-benzopyran-4-yl)Weinreb-α-aminoamides were prepared from 4-chlorocoumarin and α-aminoacid derivatives. Their reaction with organometallic compounds (RLi or RMgBr) and subsequent cyclization of ketones thus obtained, give [1]benzopyrano[4,3-b]pyrrol-4(1H)-ones. Starting from proline derivatives, simultaneously with the pyranone-pyrrole fusion, we establish an interesting procedure for the formation of pyrrolizines.

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