Add time:08/17/2019         Source:sciencedirect.com

Nearly 800 compounds have been studied for ability to inhibit glycolysis of salivary sediment. These compounds possessed aldehyde, ketone and/or carboxyl groups as a part of the organic structure. The compounds were tested mainly at 1% concentration or half-saturation, in water or in 10% propylene glycol.The most active aldehydes were formaldehyde, succinaldehyde, pyruvic aldehyde, mucochloric acid, 5-nitrosalicylaldehyde and m-hydroxybenzaldehyde. Inhibition can be attributed to the aldehyde group of the first three compounds. Nearly all active aldehydes possessed a high degree of specificity.Among ketones there were nine organic structures which were capable of producing inhibition amounting to 50 per cent or more, but only for one substance, dioleyl ketone, could inhibition be attributed definitely to the keto group.Among others, such as pyruvic aldehyde, 2,3-butanedione-2-methoxime, Rose Bengal, 2-(dibutylamino)-ethylphenylketone and 2,4′-dihydroxybenzophenone, the inhibitory action was attributable to some group other than ketone. The three remaining inhibitory chemicals, verbenone, benzoquinone and 2,5-dimethylparaquinone possessed ketone as the sole functional group.Among the eight organic acids showing inhibitory activity, there was a high degree of specificity. One group, bromacetate, mucochlorate and alphabromopropionate, was related to iodoacetate, but all were less inhibitory. Sodium N-lauroylsarcosinate was inhibitory, but few similar structures were available for comparison. The 3,5-di-iodosalicylic acid probably owes its activity to the presence of the two halogens since loss of one of these produces an inactive structure, but 2-butyl-x-chlorophenoxyacetic has activity which is not possessed by closely related compounds. The two substances, 2-cyclopentene-1-valeric acid and cyclohexanebutyric acid are the only structures whose activity could apparently be attributed to the carboxyl group.

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