1-(2-Chloroethoxy)ethyl group for the protection of 2′-hydroxyl group in the synthesis of oligoribonucleotides-Science-Chemical Encyclopedia-lookchem

1-(2-Chloroethoxy)ethyl group for the protection of 2′-hydroxyl group in the synthesis of oligoribonucleotides
Add time:08/22/2019 Source:sciencedirect.com

The 1-(2-chloroethoxy)ethyl (Cee) group is completely stable under the acidic condition required to remove the 5′-protecting groups in oligonucleotide synthesis, but can be cleaved under the similar conditions to that of the tetrahydropyranyl (Thp) in the region of pH 2–3.

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