Add time:07/13/2019 Source:sciencedirect.com
Novel tricyclic pyrimido[1,2-b]indazole-3-carbonitrile derivatives containing both biologically active pyrimidine and indazole templates are synthesized by three-component reaction of 1H-indazol-3-amine, aldehydes, and malononitrile catalyzed by base di-n-butylamine (DBA) in ethanol. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purifications.
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